Mitchell Research Group

Natural Products Inspired Organic Synthesis: An Enduring Platform for Training Next Generation Scientists

Dr. John Goodell

Dr. Goodell received his B.S. in Chemistry from the University of Wisconsin-River Falls in 2000.  He joined the research group of Prof. David Ferguson at University of Minnesota  and completed his Ph.D. in Medicinal Chemistry in 2006 with a  focus on the synthesis and evaluation of heterocyclic anti-viral agents.  He then spend 4 years as a postdoctoral associate at the Center for Chemical Methodology and Library at Boston University (CMLD-BU) under the supervision of Prof. John Porco.  His projects included the development of an automated microfluidics reactor platform in collaboration with MIT and Pfizer, Inc.  and the discovery of novel chemotypes using multidimensional reaction screening in collaboration with Merck, Inc. and Jeffrey Aubé at University of Kansas.  Dr. Goodell left the CMLD-BU in late 2010 to work with Prof. Peter Wipf  at the University of Pittsburgh Center for Chemical Methodologies & Library Development (UP-CMLD) where he worked on the development and synthesis of medium sized libraries.
 
EDUCATION
 
Illinois State University, Normal, IL (2011-present)
Research Associate (Civil Service), Chemistry Department
 
University of Pittsburgh, Pittsburgh, PA (2010-2011)
Postdoctoral Advisor: Professor Peter Wipf
 
Boston University, Boston, MA (2006-2010)
Postdoctoral Advisor: Professor John Porco
 
University of Minnesota, Minneapolis, MN (Ph.D. Medicinal Chemistry, 2006)
Doctoral Advisor: Professor David Ferguson
 
University of Wisconsin, River Falls, WI (B.S. Chemistry, 2000)
 
PUBLICATIONS
 
Benoit, A. R.; Schiaffo, C.; Salomon, C. E.; Goodell, J. R.; Hiasa, H.; Ferguson, D. M. Synthesis and evaluation of N-alkyl-9-aminoacridines with antibacterial activity. Bioorganic & Medicinal Chemistry Letters, 2014, 24, 3014–3017
 
Simanis, J. A.; Law, C. M.; Woodall, E. L.; Hamaker, C. G.; Goodell, J. R.; Mitchell, T. A. Investigation of Oxidopyrylium-Alkene [5+2] Cycloaddition Conjugate Addition Cascade (C3) Sequences. Chem. Commun. 2014, 50, 9130-9133.
 
Martin, V. I.; Goodell, J. R.; Ingham, O. J.; Porco, J. A.; Beeler, A. B. Multidimensional Reaction Screening for Photochemical Transformations as a Tool for Discovering New Chemotypes. J. Org. Chem. 2014, 79, 3838-3846.
 
LaPorte, M. G.; Goodell, J. R.; Tsegay, S.; Wipf, P. (2013) Chapter 5: Domino Reactions in Library Synthesis. In. A. Trabocchi (Ed.) Diversity-Oriented Synthesis: Basics and Applications in Organic Synthesis: Basics and Applications in Organic Synthesis, Drug Discovery, and Chemical Biology (pp. 135-176). John Wiley & Sons, Inc. 
 
Woodall, E. L; Simanis, J. A.; Hamaker, C. G.; Goodell, J. R.; Mitchell, T. A. Unique Reactivity of anti– and syn-Acetoxypyranones en Route to Oxidopyrylium Intermediates Leading to a Cascade Process. Org. Lett. 201315, 3270-3273. 
 
Brummond, K. M.; Goodell, J. R.; LaPorte, M. G.; Wang, L.; Xie, X.-Q. Synthesis and In Silico Screening of a β-Carboline-Containing Compounds.Beilstein J. Org. Chem. 2012, 8, 1048.
 
Pimparkar, Ketan; Yen, Bernard; Goodell, John R.; Martin, Veronique I.; Lee, Wen-Hsuan; Porco, John A., Jr.; Beeler, Aaron B.; Jensen, Klavs F. Development of a Photochemical Microfluidics Platform. J. Flow Chem., 2011, 2, 53.
 
Goodell, John R.;  Poole, Jennifer L.; Aubé, Jeffery; Beeler, Aaron B.; Porco, John A., Jr  Synthesis and Reactivity of Bicyclo[3.2.1]octanoid-Derived Cyclopropanes. J.Org. Chem., 2011,76, 9792.
 
Goodell, John R.; Beeler, Aaron B.; Porco, John A., Jr. Multidimensional Screening of Condensation Reactions: Application to Asymmetric 1,2-Diketones and a-Hydroxyketones.  Synthesis, 2010, 13, 2254.
 
Treece, Jennifer L.; Goodell, John R.;  Velder, David V.; Porco, John A., Jr.; Aubé, Jeffery.  Reaction Discovery Using Microfluidic-Based Multidimensional Screening of Bicyclic Iminium Ethers.  J. Org. Chem. 2010, 75, 2028.
 
Giri, Rajan, Goodell, John R.; Xing, Chenguo; Benoit,Adam; Hiasa, Hiroshi; Ferguson, David M. Synthesis and Cancer Cell Cytotoxicity of Substituted Xanthenes. Bioorg. Med. Chem. 2010 18, 1456.
 
Goodell, John R.; McMullen, Jonathan P.; Zaborenko, Nikolay; Maloney, Jason R.; Ho, Chuan-Xing; Jensen, Klavs F.; Porco, John A. Jr.; Beeler, Aaron B.   Development of an Automated Microfluidic Reaction Platform for Multidimensional Screening: Reaction Discovery Employing Bicyclo[3.2.1]octanoid Scaffolds. J. Org. Chem. 2009, 74, 6169-6180.
 
Oppegard, Lisa M.; Ougolkov, Andrei V.; Luchini, Doris N.; Schoon, Renee A.; Goodell, John R.; Kaur, Harneet; Billadeau, Daniel D.; Ferguson, David M.; Hiasa, Hiroshi.   Novel Acridine-Based Compounds that Exhibit an Anti-Pancreatic Cancer Activity are Catalytic Inhibitors of Human Topoisomerase II.    Eur. J. Pharm. 2009, 602(2-3),  223-229.
 
Goodell, John R.; Ougolkov, Andrei V.; Hiasa, Hiroshi; Kaur, Harneet; Remmel, Rory; Billadeau, Daniel D.; Ferguson, David M.   Acridine-Based Agents with Topoisomerase II Activity Inhibit Pancreatic Cancer Cell Proliferation and Induce Apoptosis.    J. Med. Chem. 200851(2),  179-182.
 
Goodell, John; Madhok, Avni; Hiasa, Hiroshi; Ferguson, David.  Synthesis and Evaluation of Acridine- and Acridone-Based Anti-Herpes Agents with Topoisomerase Activity.  Bioorg. Med. Chem. 2006, 14(16), 5467-5480.
 
Goodell, John; Svensson, Bengt; Ferguson, David.  Spectrophotometric Determination and Computational Evaluation of the Rates of Hydrolysis of 9-Amino-Substituted Acridines.  J. Chem. Inf. Model.2006, 46(2), 876-883.
 
Goodell, John; Puig-Basagoiti, Francesc; Forshey, Brett; Shi, Pei-Yong; Ferguson, David.  Identification of Compounds with Anti-West Nile Virus Activity.  J. Med. Chem. 2006, 49(6), 2127-2137.
 
Wang, Xiaodong; Hart, Scott; Xu, Bailing; Mason, Matthew; Goodell, John; Etzkorn, Felicia.  Serine-cis-proline and Serine-trans-proline Isosteres: Stereoselective Synthesis of (Z)- and (E)-Alkene Mimics by Still-Wittig and Ireland-Claisen Rearrangements.  J. Org. Chem. 2003, 68, 2343-2349.

 

Patents

Ferguson, David M.; Goodell, John R.; Hiasa, Hiroshi; Slaton, Joel W.; Billadeau, Daniel D.   Antitumor Catalytic Topoisomerase II Inhibitors.  PCT Int. Appl.  (2009), 58pp.  CODEN: PIXXD2 WO  2009076212 A1 20090618 CAN 151:70263  AN 2009:737713

Ferguson, David M.; Goodell, John R.   Pyrazoline Derivatives for Treatment of Viral Infections.    PCT Int. Appl.  (2007),  78pp.  CODEN: PIXXD2  WO  2007038425  A2  20070405  CAN 146:395241  AN 2007:384400

Professional Presentations

Oral Presentations

“Multidimensional Screening and Methodology Development for Condensations Involving Complex 1,2-Diketones” ACS National Meeting,Boston, August 22, 2010.

“Developing Technologies for Reaction Discovery” Cambridge Healthtech Institute: High-Throughput Organic Synthesis & Purification Conference,La Jolla,California, May 15, 2007.

“Discovery and Development of Compounds with Anti-West Nile Virus Activity,” American Chemical Society: the 37th Great Lakes Regional Meeting, Milwaukee, Wisconsin, June 2, 2006.

  • Recent News

    Congratulations to Marshall Law for successfully defending his thesis! 7-23-15

    Congratulations to Jasmine, Katya, Laina, Camille, Jessica, and Alexandra for graduating from the Illinois Summer Research Academy! 7-18-14

    Congratulations to Christian Zwick who graduated with his B.S. (Chemistry) in May 2015!

    Congratulations to Brendan Thompson who graduated with his B.S. (Chemistry) in May 2015!

    Congratulations to Stacie Cler who graduated with her B.S. (Chemistry) in May 2015!

    Congratulations to Justin, Christian, Marshall, Erica, and John for their recent paper in Heterocycles! 1-15-15

    Congratulations to Chris Olson who graduated with his B.S. (Chemistry) in December 2014!

    Congratulations to Greg, Alexandria, Jason, Robert, and Kevin for graduating from the Illinois Summer Research Academy! 7-18-14

    Congratulations to Justin, Marshall, Erica, and John for their recent paper in ChemComm! 7-3-14

    Congratulations to Justin Simanis for successfully defending his M.S. thesis! 6-16-14

    Congratulations to Marshall Law who graduated with his B.S. (Biochemistry) in December 2013!

    Congratulations to Erica Woodall for successfully defending her M. S. thesis! 10-14-13

    Congratulations to Courtnay for her recent paper in Synlett! 7-10-13

    Congratulations to Erica, Justin, and John for their recent paper in Organic Letters! 6-21-13

    Congratulations to Erin Mortimer who graduated with her B.S. (Biology) in May 2013!

    Congratulations to Sydney Roche who graduated with her B.S. (Biochemistry) in May 2013!

    Congratulations to Patrick Leszczynski who graduated with his B.S. (Chemistry) in December 2012!

    Congratulations to Courtnay Shaner for successfully defending her M.S. thesis! 9-20-12

    The group was recently awarded a Cottrell College Science Award from the Research Corporation for Scientific Advancement! 7-1-12

    The group was recently awarded a Petroleum Research Fund - Undergraduate New Investigator Award from the American Chemical Society! 9-1-12

    Congratulations to Justin Simanis who graduated with his B.S. (Chemistry) in May 2012!

    Congratulations to Dave Ferge who graduated with his B.A. (English) in May 2012!

    Congratulations to Louis Bajek who graduated with his B.S. (Chemistry) in May 2011!

    Congratulations to Matt Beio who graduated with his B.S. (Biochemistry) in May 2011!